Document Detail

Metabolic energy availability and proliferative activity in adriamycin-treated cells.
MedLine Citation:
PMID:  2705748     Owner:  NLM     Status:  MEDLINE    
Metabolic energy availability and proliferative activity were studied in HeLa cells treated with Adriamycin (Adr). Conditions (ID50) that induced growth delay, without significant cell lethality, did not appreciably alter ATP content, over 72 hours after treatment. Energy-dependent membrane permeability properties, assessed with the vital dye fluorescein, were similarly unaffected. The cytostatic effect was confirmed by the incorporation rate of 3H-thymidine and 14C-leucine, and by flow cytometric analysis of cell cycle progression. Early depletion in cellular ATP occurred when Adr induced an evident cytocidal effect.
E Prosperi; A C Croce; R Supino; G Bottiroli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  9     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1989 Jan-Feb
Date Detail:
Created Date:  1989-05-23     Completed Date:  1989-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Dipartimento di Biologia Animale, Università di Pavia, Italy.
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MeSH Terms
Adenosine Triphosphate / analysis
Cell Cycle / drug effects
Cell Division / drug effects
DNA / biosynthesis
Doxorubicin / pharmacology*
Energy Metabolism / drug effects*
Hela Cells
Reg. No./Substance:
23214-92-8/Doxorubicin; 56-65-5/Adenosine Triphosphate; 9007-49-2/DNA

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