Document Detail


Metabolic effects of voluntary wheel running in young and old Syrian golden hamsters.
MedLine Citation:
PMID:  16386768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To explore the metabolic effects of high volume wheel running in the Syrian golden hamster, 6-week old (YOUNG) and 6-month old (OLD) male animals were randomly divided into sedentary (i.e., YOUNG-S or OLD-S) or running wheel (i.e., YOUNG-RW or OLD-RW) groups (n = 8/group). RW groups had 24-h access to activity wheels while S were housed in standard rodent cages. At the start of wheel exposure, the number of revolutions were similar in both groups, but by day 15 were nearly two-fold higher in the YOUNG vs. OLD. OLD ate more than YOUNG and wheel running increased food intake by approximately 50%. YOUNG-RW maintained the same total body mass as YOUNG-S, while OLD-RW had a transient weight loss of approximately 10 g. Perirenal fat mass was smaller in YOUNG- and OLD-RW groups compared with S groups (45% and 66%, respectively. Plantaris muscle cytochrome c oxidase activity was also approximately 2-fold higher in YOUNG-RW than in YOUNG-S hamsters but was similar between OLD-RW and OLD-S groups. Plasma leptin levels were approximately 60% lower in YOUNG-RW compared with YOUNG-S and correlated significantly with visceral fat pad mass (r2 = 0.58, p = 0.001). Corticosterone levels were lower in YOUNG-RW (13.0 +/- 0.36 ng/ml) than in YOUNG-S (16.4 +/- 0.83 ng/ml) hamsters and higher in OLD-RW (22.62 +/- 0.47 ng/ml) than in OLD-S (15.54 +/- 0.13 ng/ml) hamsters. These observations reveal that the hamster is a suitable model for accelerating the effects of exercise on body composition and metabolic alterations associated with training and that the training adaptations are more pronounced in younger compared with older hamsters, possibly as a result of the higher voluntary wheel activity in the former group.
Authors:
Agnes E Coutinho; Sergiu Fediuc; Jonathan E Campbell; Michael C Riddell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-04
Journal Detail:
Title:  Physiology & behavior     Volume:  87     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-7     Citation Subset:  IM    
Affiliation:
School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, 4700 Keele Street, Toronto, ON, Canada, M3J 1P3.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology
Aging / physiology*
Animals
Blood Glucose / metabolism
Body Composition / physiology
Body Weight / physiology
Corticosterone / blood
Cricetinae
Data Interpretation, Statistical
Eating / physiology
Electron Transport Complex IV / metabolism
Hormones / blood
Male
Mesocricetus
Muscle, Skeletal / enzymology,  physiology
Organ Size / physiology
Running / physiology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hormones; 50-22-6/Corticosterone; EC 1.9.3.1/Electron Transport Complex IV

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