Document Detail


Metabolic effects of training in humans: a 31P-MRS study.
MedLine Citation:
PMID:  2246165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the feasibility of measuring with 31P nuclear magnetic resonance the effects of an endurance training program on the high-energy phosphate metabolism of exercising human skeletal muscle. The system used included a 1.9-T 30-cm-bore Oxford Systems superconducting magnet, a PhosphoEnergetics spectrometer, and a modified Cybex isokinetic ergometer. Seven healthy human volunteers exercised their wrist flexor muscles 20 min/day 5 days/wk for 8 wk. Testing before and after the training period consisted of a performance test to measure muscle functional capacity and a ramp test to measure the work-energy cost relationship of the exercising muscles. The results indicate that the subjects had a significant increase in their work output on the 10-min performance test after training. They also exhibited an increase in the work-energy cost relationship on the ramp test as indicated by a decrease in peak Pi-to-phosphocreatine ratio and an increase in pH at the same relative power output after training. These results indicate that 1) the training program was sufficient to elicit a training effect and 2) this effect was observed with 31P nuclear magnetic resonance as an increased potential for oxidative metabolism, particularly at the high exercise levels.
Authors:
J A Kent-Braun; K K McCully; B Chance
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-70     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Energy Metabolism
Exercise*
Female
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Male
Muscles / metabolism*,  physiology
Phosphates / metabolism
Phosphocreatine / metabolism
Phosphorus Isotopes
Grant Support
ID/Acronym/Agency:
HL-31934/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Phosphates; 0/Phosphorus Isotopes; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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