Document Detail

Metabolic effects of proglycosyn.
MedLine Citation:
PMID:  1314546     Owner:  NLM     Status:  MEDLINE    
Proglycosyn, a phenylacyl imidazolium compound that lowers blood glucose levels, was demonstrated previously to promote hepatic glycogen synthesis, stabilize hepatic glycogen stores, activate glycogen synthase, inactivate glycogen phosphorylase, and inhibit glycolysis. In the present study proglycosyn was found to inhibit fatty acid synthesis, stimulate fatty acid oxidation, and lower fructose 2,6-bisphosphate levels, but to have no significant effects on cell swelling and the levels of cAMP in hepatocytes prepared from fed rats. Verapamil and atropine blocked the effects of proglycosyn on glycogen metabolism, but these compounds inhibit proglycosyn accumulation by hepatocytes. Proglycosyn stimulated phosphoprotein phosphatase activity in postmitochondrial extracts, as measured by dephosphorylation of phosphorylase a and glycogen synthase D, but this action required a very high concentration of the compound, making it unlikely to be the actual mechanism involved. It is proposed that a metabolite of proglycosyn is responsible for its metabolic effects.
K Yamanouchi; T W Stephens; K Chikada; S J Dominianni; H Behforouz; P Scislowski; A DePaoli-Roach; D W Allmann; R A Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  294     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-15     Completed Date:  1992-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-15     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122.
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MeSH Terms
8-Bromo Cyclic Adenosine Monophosphate / pharmacology
Atropine / pharmacology
Cells, Cultured
Cyclic AMP / metabolism*
Glucagon / pharmacology
Glycogen Synthase / metabolism*
Hypoglycemic Agents / pharmacology*
Imidazoles / pharmacology*
Liver / drug effects,  metabolism*
Liver Glycogen / metabolism
Phosphoprotein Phosphatases / metabolism
Phosphorylase a / metabolism*
Rats, Inbred Strains
Verapamil / pharmacology
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Imidazoles; 0/Liver Glycogen; 103793-22-2/proglycosyn; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 51-55-8/Atropine; 52-53-9/Verapamil; 60-92-4/Cyclic AMP; 9007-92-5/Glucagon; EC 2.4.1.-/Phosphorylase a; EC Synthase; EC Phosphatases

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