Document Detail


Metabolic effects of obstetric regional analgesia and of asphyxia in the newborn infant during the first two hours after birth. II. Arterial plasma concentrations of glycerol, free fatty acids and beta-hydroxybutyrate.
MedLine Citation:
PMID:  7324934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of obstetric regional analgesia and of asphyxia on the arterial blood concentrations of the lipid metabolites: glycerol, free fatty acids and beta-hydroxybutyrate were investigated in 85 newborn infants divided into a control group, an asphyxia group, a continuous epidural, an intermittent epidural and a paracervical + pudendal block group: lidocaine was the drug used in the analgesia groups. The postnatal changes in lipid metabolites followed three different patterns. After marked increases in glycerol and free fatty acids a steady level was reached after one hour in the control group and not before two hours in the regional analgesia groups. In the asphyxia group, however, a steady level was found already 10 min after birth. Between 30 and 120 min after birth the beta-hydroxybutyrate concentration increased in the control group, decreased in the asphyxia group and did not change in the three regional analgesia groups. The different patterns of lipid metabolites may indicate differences in sympathetic tone and/or in hormonal influences after birth.
Authors:
S Swanström; L E Bratteby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  70     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  801-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid
Anesthesia, Caudal / adverse effects
Anesthesia, Epidural / adverse effects
Anesthesia, Obstetrical / adverse effects*
Asphyxia Neonatorum / blood*
Fatty Acids, Nonesterified / blood*
Female
Glycerol / blood*
Humans
Hydroxybutyrates / blood*
Infant, Newborn*
Lidocaine / adverse effects
Maternal-Fetal Exchange
Pregnancy
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 137-58-6/Lidocaine; 300-85-6/3-Hydroxybutyric Acid; 56-81-5/Glycerol

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