Document Detail

Metabolic effects of green tea and of phases of weight loss.
MedLine Citation:
PMID:  16277999     Owner:  NLM     Status:  MEDLINE    
The effect of ingestion of green tea (GT) extract along with a low-energy diet (LED) on health-related blood parameters, and the relationships among changes in metabolic parameters and phases of weight loss were assessed. A double-blind, placebo-controlled, parallel design was used. 46 female subjects (BMI 27.7+/-1.8 kg/m(2)) were fed in energy balance from days 1 to 3, followed by a LED with GT (n=23) or placebo (PLAC, n=23) from days 4 to 87. The LED-period consisted of a phase 1 of 4 weeks (days 4-32) followed by a phase 2 of 8 weeks (days 32-87). Body composition and fasting blood samples were determined on days 4, 32 and 87. No significant differences were observed between the blood parameters of the PLAC and GT group. In phase 1 compared to phase 2 the rate of weight loss was 0.09+/-0.05 kg/day vs. 0.03+/-0.03 kg/day (p<0.001); Fat free mass (FFM) was 21% of weight loss in phase 1 vs. 7% in phase 2 (ns). Surprisingly, favourable changes in free fatty acids, triacylglycerol, beta-hydroxybutyrate, glucose and total cholesterol in phase 1 were reversed in phase 2 (p<0.01). Taken together, GT supplementation during a LED had no effect on health-related blood parameters. Initial improvements in several blood measures at day 32 were reversed by day 87, despite continued weight loss. Modest weight loss improved HDL cholesterol and blood pressure.
K Diepvens; E M R Kovacs; N Vogels; M S Westerterp-Plantenga
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-11-07
Journal Detail:
Title:  Physiology & behavior     Volume:  87     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Maastricht University, Department of Human Biology, P.O. Box 616 NL-6200 MD, Maastricht, The Netherlands. K.Diepvens@HB.Unimaas.NL
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MeSH Terms
Administration, Oral
Analysis of Variance
Body Mass Index
Body Weight / drug effects,  physiology
Camellia sinensis*
Catechin / administration & dosage*
Double-Blind Method
Energy Intake
Energy Metabolism / drug effects*,  physiology
Leptin / blood
Middle Aged
Plant Extracts / administration & dosage*
Reference Values
Regression Analysis
Triglycerides / blood
Weight Loss / drug effects*,  physiology
Reg. No./Substance:
0/Leptin; 0/Plant Extracts; 0/Tea; 0/Triglycerides; 154-23-4/Catechin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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