| Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients. | |
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MedLine Citation:
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PMID: 7694879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postoperative diabetes is a reported feature of the immunosuppressive agents cyclosporin A and FK 506. To date, however, no randomized comparative studies of the metabolic effects of these two drugs have been performed. In this study, extended (300 min) oral glucose tolerance tests (75 g) were performed a median of 8 mo (range 5-9 mo) postoperatively in 20 clinically stable liver transplant recipients randomly allocated to maintenance immunosuppression with either cyclosporin A (with or without azathioprine) or FK 506. None of the patients had clinically overt diabetes antedating transplantation. To avoid the confounding effects of corticosteroids, prednisolone was withdrawn at least 6 wk beforehand in each case. Ten healthy volunteers matched for age and body mass index served as control subjects. Overall blood glucose concentrations after the glucose challenge were significantly elevated in both groups of transplant recipients (P < 0.005 and P < 0.001 for cyclosporin A and FK 506 treatment groups, respectively) compared with the healthy control subjects. Venous whole-blood glucose concentration (mean +/- SE) 120 min after the ingestion of oral glucose was significantly higher in both the cyclosporin A (P < 0.05) and FK 506 (P < 0.01) treatment groups compared with the control subjects (6.6 +/- 0.5 vs. 8.8 +/- 0.9 vs. 5.2 +/- 0.2 mM, respectively). According to 1985 WHO criteria, 4 of 10 cyclosporin A-treated patients had impaired glucose tolerance, whereas 3 of 10 FK 506-treated patients had diabetes with 4 others having impaired glucose tolerance.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A J Krentz; B Dousset; D Mayer; P McMaster; J Buckels; R Cramb; J M Smith; M Nattrass |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Diabetes Volume: 42 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1993-12-28 Completed Date: 1993-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1753-9 Citation Subset: AIM; IM |
Affiliation:
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Diabetic Clinic, General Hospital, Birmingham, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Azathioprine / therapeutic use Blood Glucose / metabolism* Body Mass Index C-Peptide / blood Cyclosporine / therapeutic use* Fatty Acids, Nonesterified / blood Female Glucose Tolerance Test* Glycerol / blood Humans Insulin / blood* Ketone Bodies / blood Lactates / blood Liver Transplantation / physiology* Male Middle Aged Prospective Studies Pyruvates / blood Pyruvic Acid Reference Values Tacrolimus / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 0/Lactates; 0/Pyruvates; 109581-93-3/Tacrolimus; 11061-68-0/Insulin; 127-17-3/Pyruvic Acid; 446-86-6/Azathioprine; 56-81-5/Glycerol; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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