Document Detail


Metabolic effects of clofibrate on experimental animals.
MedLine Citation:
PMID:  582692     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of ethyl-alpha-(p-chlorophenoxy)-isobutyrate (clofibrate, Miscleron) on certain parameters of lipid and carbohydrate metabolism was studied in male and female white rats. The vitamin A content and the mixed function oxydase activity in the liver was also examined. 1. In short-term experiments over 10 to 30 days clofibrate significantly influenced the examined parameters. In a long-term experiment (9 months), however, these changes were no more observable. 2. Clofibrate exerted a protective effect against lipid mobilization following physical exercise (swimming). 3. No significant differences between male and female rats after clofibrate treatment could be observed.
Authors:
M Bedö; M Kramer; A Blaskovits; G Gefferth; R Tarjan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  28     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1978  
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1076-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Clofibrate / pharmacology*
Female
Kidney / metabolism
Lipid Metabolism
Lipids / blood
Liver / metabolism
Male
Metabolism / drug effects*
Physical Exertion
Rats
Sex Factors
Swimming
Time Factors
Chemical
Reg. No./Substance:
0/Lipids; 637-07-0/Clofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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