| Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. | |
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MedLine Citation:
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PMID: 16886964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Whereas caffeine has been demonstrated to impact substantially on the metabolic response to exercise in healthy young subjects, this issue remains to be addressed in healthy elderly subjects. DESIGN AND PATIENTS: The metabolic response to caffeine ingestion (6 mg/kg) and exercise in healthy elderly citizens at 70 years was examined in a randomized, double-blind, placebo-controlled, cross-over study. We included 30 subjects attending for driver license renewal at their general practitioner. Participants abstained from caffeinated drinks and food for 48 h and were randomized to receive placebo-caffeine or caffeine-placebo with 1 week between sessions. MEASUREMENTS: A cycling endurance test at 65% of the expected maximal heart rate was performed 1 h after intervention. Blood samples were taken before intervention, before cycling, after 5 min of cycling, and at exhaustion. Analysis was by intention-to-treat and P < 0.05 was regarded as significant. RESULTS: Caffeine significantly increased the concentration of plasma epinephrine (by 42%, 39%, and 49%), serum-free fatty acids (by 53%, 44%, and 50%), and plasma lactate (by 46%, 36%, and 48%), and insulin resistance (homeostasis model assessment-IR) (by 21%, 26%, and 23%) during rest, after 5 min of cycling, and at exhaustion. At exhaustion, the concentration plasma norepinephrine was elevated by 29%. A decrease was seen with caffeine treatment in blood potassium after 5 min of cycling and at exhaustion (by 3% and 2%, respectively). CONCLUSIONS: Caffeine treatment increased epinephrine, fatty acids, lactate and norepinephrine at different times during test session and led to insulin-resistance. Hence, caffeine ingestion elicits a similar metabolic response in elderly participants at 70 years old to that seen in younger subjects. |
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Authors:
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C B Norager; M B Jensen; A Weimann; M R Madsen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical endocrinology Volume: 65 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: IM |
Affiliation:
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Surgical Research unit, Surgical Department, Herning Hospital, Copenhagen, Denmark. heccbn@ringamt.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Blood Glucose / metabolism Caffeine / administration & dosage* Calcium / blood Cross-Over Studies Double-Blind Method Energy Metabolism / drug effects* Epinephrine / blood Exercise Test Fatty Acids, Nonesterified / blood Female Homeostasis Humans Insulin / blood Insulin Resistance Lactic Acid / blood Male Potassium / blood Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 51-43-4/Epinephrine; 58-08-2/Caffeine; 7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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