Document Detail


Metabolic effects of a biphasic oral contraceptive preparation containing ethinyloestradiol and desogestrel on serum lipoproteins and apolipoproteins.
MedLine Citation:
PMID:  2946795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the administration of a biphasic oral contraceptive containing ethinyloestradiol and desogestrel on the distribution and composition of serum lipoproteins was studied in a group of 17 healthy female volunteers. The women were treated for a period of 6 months and compared with a control group of ten untreated volunteers. The serum lipoproteins were fractionated by density gradient ultracentrifugation into very low density lipoproteins (VLDL), low density lipoproteins (LDL), and into the high density lipoprotein (HDL) subfractions 2 and 3 (HDL2, HDL3). Lipids and apolipoproteins were assayed in the various fractions. No modification of either the lipid or apolipoprotein concentrations was observed in the control group. In the treated group, sex hormone-binding globulin (SHBG) and cortisol-binding globulin (CBG), and the serum content of cholesterol, triglycerides, HDL-cholesterol, apolipoprotein A-I (apo A-I) and apolipoprotein A-II (apo A-II) increased significantly after 3 and 6 months. The cholesterol and apolipoprotein B (apo B) content of VLDL increased significantly after 3 and 6 months, but remained unchanged in LDL. High density lipoprotein subfraction 2 (HDL2)-cholesterol was significantly increased after 3 and 6 months but apo A-I only after 6 months. Since apo A-II did not change, the apo A-I/A-II ratio increased significantly after 6 months of treatment. In the HDL3 fraction, the apo A-I increase was significant after 3 and 6 months, while the increase of apo A-II was significant after 6 months. The apo A-I/A-II ratio remained constant.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
L Voorhoof; M Rosseneu; H Caster; W De Keersgieter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  111     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-12     Completed Date:  1987-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins / blood*
Apolipoproteins A / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Contraceptives, Oral, Combined / pharmacology*
Desogestrel
Ethinyl Estradiol / pharmacology
Female
Humans
Lipoproteins / blood*
Lipoproteins, VLDL / blood
Norpregnenes / pharmacology
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoproteins; 0/Apolipoproteins A; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Contraceptives, Oral, Combined; 0/Lipoproteins; 0/Lipoproteins, VLDL; 0/Norpregnenes; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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