Document Detail

Metabolic effects of alterations in meal frequency in hypercholesterolaemic individuals.
MedLine Citation:
PMID:  7980716     Owner:  NLM     Status:  MEDLINE    
It has been suggested that the metabolic consequences of a given diet may depend in part on the frequency with which meals are eaten. To investigate the effects of meal frequency on plasma lipid metabolism, 16 free-living hypercholesterolaemic men and women consumed their usual diet as 3 or 9 meals/day in random order for 4 weeks. Dietary macronutrient intake and body weight remained similar on the 2 regimens. Fasting plasma lipids were measured after 2, 3 and 4 weeks on each regimen and there were no significant differences in the fasting concentrations of plasma total, LDL, and HDL cholesterol, triglycerides, apolipoprotein A-I and B and the ratio of total: LDL and LDL:HDL cholesterol (HDL-C) on the two diets. The mean (+/- S.D.) fasting total cholesterol was 6.73 +/- 0.74 and 6.81 +/- 0.88 mmol/l on 3 and 9 meals/day, respectively and LDL-C was 4.77 +/- 0.66 and 4.87 +/- 0.78 mmol/l, respectively. There was also no significant variation in the response of plasma triglycerides or serum insulin to a high fat meal following a 3 week adaptation to regimens of 3 and 9 meals/day. Finally the 24 h urinary output of C-peptide was similar on each diet. The consumption of isoenergetic diets as 3 and 9 meals/day did not influence fasting plasma lipid levels, C-peptide excretion or the plasma triglyceride response to a high fat meal of a group of free living hypercholesterolaemic subjects.
L Arnold; M Ball; J Mann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Atherosclerosis     Volume:  108     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-23     Completed Date:  1994-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Blood Glucose / analysis
C-Peptide / blood
Cholesterol / blood
Creatinine / blood
Cross-Over Studies
Dietary Fats / administration & dosage
Hypercholesterolemia / blood*
Insulin / blood
Lipids / blood*
Middle Aged
Time Factors
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Dietary Fats; 0/Lipids; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 60-27-5/Creatinine

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