| Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. | |
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MedLine Citation:
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PMID: 21976521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolic syndrome has deleterious effects on the CNS, and recent evidence suggests that obesity rates are higher at presentation in children who develop epilepsy. Adiponectin is secreted by adipose tissue and acts in the brain and peripheral organs to regulate glucose and lipid metabolism. Adiponectin deficiency predisposes toward metabolic syndrome, characterized by obesity, insulin resistance, impaired glucose tolerance, hyperlipidemia, and cardiovascular morbidity. To investigate the relationship between metabolic syndrome and seizures, wild-type C57BL/6J and adiponectin knock-out mice were fed a high-fat diet, followed by treatment with low doses of kainic acid to induce seizures. Adiponectin deficiency in mice fed a high-fat diet resulted in greater fat accumulation, impaired glucose tolerance, hyperlipidemia, increased seizure severity, and increased hippocampal pathology. In contrast, there were no adverse effects of adiponectin deficiency on metabolic phenotype or seizure activity in mice fed a normal (low-fat) chow diet. These findings demonstrate that metabolic syndrome modulates the outcome of seizures and brain injury. |
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Authors:
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Edward B Lee; Genevieve Warmann; Ravindra Dhir; Rexford S Ahima |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: 2011-11-18 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 14361-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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deficiency* Adipose Tissue / metabolism Animals Blood Glucose / metabolism Hippocampus / metabolism, pathology Kainic Acid / toxicity* Metabolic Syndrome X / metabolism*, pathology Mice Mice, Inbred C57BL Mice, Knockout Seizures / chemically induced, metabolism*, pathology Severity of Illness Index* |
| Grant Support | |
ID/Acronym/Agency:
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K08 AG039510-01/AG/NIA NIH HHS; K08-AG039510/AG/NIA NIH HHS; P01 DK049210-14/DK/NIDDK NIH HHS; P01-DK-049210/DK/NIDDK NIH HHS; P30 DK019525-34/DK/NIDDK NIH HHS; P30-DK19525/DK/NIDDK NIH HHS; R01 DK062348-08/DK/NIDDK NIH HHS; R01-DK-062348/DK/NIDDK NIH HHS; T32 AG000255-10/AG/NIA NIH HHS; T32-AG00255/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Blood Glucose; 487-79-6/Kainic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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