Document Detail

Metabolic diversification of cells during the development of yeast colonies.
MedLine Citation:
PMID:  19196279     Owner:  NLM     Status:  MEDLINE    
Microorganisms in nature form organized multicellular structures (colonies, biofilms) possessing properties absent in individual cells. These are often related to the better ability of communities to survive long-lasting starvation and stress and include mechanisms of adaptation and cell specialization. Thus, yeast colonies pass through distinct developmental phases characterized by changes in pH and the production of ammonia-signalling molecules. Here, we show that Saccharomyces cerevisiae colony transition between major developmental phases (first acidic, alkali, second acidic) is accompanied by striking transcription changes, while the development within each particular phase is guided mostly at the post-transcriptional level. First- and second-acidic-phase colonies markedly differ. Second-acidic-phase colonies maintain the adaptive metabolism activated in the ammonia-producing period, supplemented by additional changes, which begin after colonies enter the second acidic phase. Cells with particular properties are not homogenously dispersed throughout the colony population, but localize to specific colony regions. Thus, cells located at the colony margin are able to export higher amounts of ammonium than central cells and to activate an adaptive metabolism. In contrast, central chronologically aged cells are unable to undergo these changes but they maintain higher levels of various stress-defence enzymes. These divergent properties of both cell types determine their consequent dissimilar fate.
Libuse Váchová; Helena Kucerová; Frederic Devaux; Miroslava Ulehlová; Zdena Palková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental microbiology     Volume:  11     ISSN:  1462-2920     ISO Abbreviation:  Environ. Microbiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883692     Medline TA:  Environ Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  494-504     Citation Subset:  IM    
Institute of Microbiology AS CR, Prague, Czech Republic.
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MeSH Terms
Adaptation, Physiological*
Ammonia / metabolism
Culture Media / chemistry
Gene Expression Regulation, Fungal*
Saccharomyces cerevisiae / growth & development*,  metabolism*
Saccharomyces cerevisiae Proteins / metabolism
Grant Support
55005623//Howard Hughes Medical Institute
Reg. No./Substance:
0/Culture Media; 0/Saccharomyces cerevisiae Proteins; 7664-41-7/Ammonia

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