Document Detail

Metabolic disturbances during myocardial ischemia and reperfusion.
MedLine Citation:
PMID:  7645523     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia is defined as an imbalance between fractional uptake of oxygen and the rate of cellular oxidation in the heart. This condition may have several potential outcomes: (1) when ischemia is brief, a transient post-ischemic ventricular dysfunction occurs on reperfusion, a condition termed "stunned myocardium"; (2) when it is prolonged and severe, irreversible damage occurs, with no recovery in contractile function upon reperfusion; (3) when ischemia is less severe, but still prolonged, the myocytes may remain viable but exhibit depressed contractile function. Under this condition, named "hibernating myocardium," the reperfusion is able to restore contractility. During these different ischemic conditions many biochemical changes happen; initially they represent a defensive and protective reaction against ischemic insults such as cellular acidosis and increase of inorganic phosphate levels that rapidly abolish the contractile activity. But with the prolongation of ischemia or restoration of the coronary flow, alterations in ions and overall Ca2+ homeostasis occur, together with an oxidative stress mediated by oxygen free radicals, which are not adequately counteracted by the cellular antioxidant defenses. All these biochemical alterations lead to membrane damage, mitochondrial swelling, and irreversible deterioration of contractile function.
R Ferrari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  76     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-19     Completed Date:  1995-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17B-24B     Citation Subset:  AIM; IM    
Cattedra di Cardiologia, Università degli Studi di Brescia, Italy.
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MeSH Terms
Coronary Circulation / physiology
Free Radicals / metabolism
Mitochondria, Heart / metabolism
Myocardial Contraction / physiology
Myocardial Ischemia / metabolism*,  physiopathology
Myocardial Reperfusion Injury / metabolism*,  physiopathology
Myocardial Stunning / metabolism
Oxygen / metabolism
Reg. No./Substance:
0/Free Radicals; 7782-44-7/Oxygen

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