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Metabolic disregulation in obese adolescents with sleep-disordered breathing before and after weight loss.
MedLine Citation:
PMID:  23408643     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Sleep-disordered breathing (SDB) is prevalent in obesity. Weight loss is one of the most effective treatment options. We aimed to assess the association of SDB and metabolic disruption before and after weight loss. DESIGN AND METHODS: Obese adolescents were included when entering an in-patient weight loss program. Fasting blood analysis was performed at baseline and after 4-6 months. Sleep screening was done at baseline and at follow-up in case of baseline SDB. RESULTS: 224 obese adolescents were included. Median age was 15.5 years (10.1-18.0) and mean BMI z-score 2.74±0.42. 30% had SDB at baseline (N=68). HDL-cholesterol was associated with mean nocturnal oxygen saturation (<SaO2>) (partial r=0.21; P=0.002). ASAT and ALAT were related with ODI (partial r=-0.15; P=0.03 and partial r=-0.15; P=0.02), but this became insignificant after correction for sex. After weight loss, 24% had residual SDB. Linear regression showed an association between ASAT and <SaO2> (partial r=-0.34; P=0.002). There were no significant correlations between improvements in laboratory measurements and sleep parameters. HDL-cholesterol improved in relation with the decrease in BMI z-score. CONCLUSION: SDB at baseline was associated with higher levels of liver enzymes and lower HDL-cholesterol concentration. Improvements in sleep parameters were not associated with improvements in laboratory measurements.
Authors:
K Van Hoorenbeeck; H Franckx; P Debode; P Aerts; J Ramet; Lf Van Gaal; Kn Desager; Wa De Backer; Sl Verhulst
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-14
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Affiliation:
Laboratory of experimental medicine and pediatrics, University of Antwerp, Antwerp, Belgium. kim.vanhoorenbeeck@ua.ac.be.
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