| Metabolic disposition of ethyl eicosapentaenoate and its metabolites in rats and dogs. | |
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MedLine Citation:
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PMID: 2842487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When orally administered to rats, 14C-labelled ethyl eicosapentaenoate (14C-EPA-E) was hydrolyzed and, in the lymph, incorporated mainly into triglycerides (TG) in chylomicrons. In plasma and other tissues, eicosapentaenoic acid (EPA) and its metabolites, such as docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), were detected in TG and phospholipid fractions. In plasma, EPA and its metabolites were found to be integrated into lipoproteins. Tissue distribution of these metabolites showed characteristic patterns from one tissue to another, as did their compositional distribution in lipids. EPA, DPA and DHA were found to be metabolized via beta-oxidation in in vitro experiments with mitochondrial fraction. |
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Authors:
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J Ishiguro; T Tada; T Ogihara; N Ohzawa; K Murakami; H Kosuzume |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 11 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-10-11 Completed Date: 1988-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 251-61 Citation Subset: IM |
Affiliation:
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Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism Animals Chromatography, High Pressure Liquid Chromatography, Thin Layer Docosahexaenoic Acids / metabolism Dogs Eicosapentaenoic Acid / analogs & derivatives*, pharmacokinetics Fatty Acids / blood Fatty Acids, Unsaturated / metabolism Lipid Metabolism Lipoproteins / metabolism Male Mitochondria, Liver / metabolism Rats Rats, Inbred Strains Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 121935-04-4/eicosapentaenoic acid-coenzyme A; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 25448-00-4/docosapentaenoic acid; 73310-10-8/eicosapentaenoic acid ethyl ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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