Document Detail


Metabolic disposition of chlorambucil in rats.
MedLine Citation:
PMID:  868079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The metabolic dispositionof chlorambucil, 4-p-(di-2-chloroethyl)aminophenylbutyric acid, was studied in the rat. 2. After oral administration of [14C]chlorambucil to rats, plasma, liver, and kidney showed the highest concentration of 14C. After intravenous administration, plasma and kidney were heavily labelled. Although plasma contained as much as 10% of the administered dose in the first few hours after administration, the level decreased to 1% by 24 h. Elimination of radioactivity was mainly through the kidney. 3. Ten metabolites were isolated and characterized by mass spectrometry. Most metabolites had undergone oxidation on the butyric acid side-chain to form phenylacetic acid and benzoic acid derivatives. Spontaneous degradation products of [14C]chlorambucil were analysed and compared with the metabolites.
Authors:
C Mitoma; T Onodera; T Takegoshi; D W Thomas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  7     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-07-23     Completed Date:  1977-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Chlorambucil / blood,  metabolism*,  urine
Chromatography, Gas
Enterohepatic Circulation
Injections, Intravenous
Intestinal Absorption
Kidney / metabolism
Liver / metabolism
Mass Spectrometry
Rats
Time Factors
Chemical
Reg. No./Substance:
305-03-3/Chlorambucil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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