| Metabolic disposition of chlorambucil in rats. | |
| | |
MedLine Citation:
|
PMID: 868079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The metabolic dispositionof chlorambucil, 4-p-(di-2-chloroethyl)aminophenylbutyric acid, was studied in the rat. 2. After oral administration of [14C]chlorambucil to rats, plasma, liver, and kidney showed the highest concentration of 14C. After intravenous administration, plasma and kidney were heavily labelled. Although plasma contained as much as 10% of the administered dose in the first few hours after administration, the level decreased to 1% by 24 h. Elimination of radioactivity was mainly through the kidney. 3. Ten metabolites were isolated and characterized by mass spectrometry. Most metabolites had undergone oxidation on the butyric acid side-chain to form phenylacetic acid and benzoic acid derivatives. Spontaneous degradation products of [14C]chlorambucil were analysed and compared with the metabolites. |
| | |
Authors:
|
C Mitoma; T Onodera; T Takegoshi; D W Thomas |
Related Documents
:
|
20540639 - Improved plasma amino acids pattern following 12 months of supplemented low-protein die... 1360309 - Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids. 4066689 - Origin of apolipoprotein a-i polymorphism in plasma. 16831699 - Muscle and plasma amino acids during semi-starvation in normal subjects: hypocaloric gl... 3052059 - Inhibition of renin by plasma linoleic acid. 6027079 - The renal clearance of amino acids in cystinuria. 6258569 - Phosphate utilization and constitutive synthesis of phosphatases in thermoactinomyces v... 12542359 - Nodulisporic acids c, c1, and c2: a series of d-ring-opened nodulisporic acids from the... 21705549 - Spatial and temporal analysis of the microbial community in the tailings of a pb-zn min... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 7 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1977 Apr |
Date Detail:
|
Created Date: 1977-07-23 Completed Date: 1977-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 205-20 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Chlorambucil / blood, metabolism*, urine Chromatography, Gas Enterohepatic Circulation Injections, Intravenous Intestinal Absorption Kidney / metabolism Liver / metabolism Mass Spectrometry Rats Time Factors |
| Chemical | |
Reg. No./Substance:
|
305-03-3/Chlorambucil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bronchobiliary fistula due to echinococcosis of the liver.
Next Document: Identification of 3-methyl-2-thiohydantoin, a metabolite of carbimazole, in man.