Document Detail

Metabolic disorders prevalence in sudden deafness.
MedLine Citation:
PMID:  21243289     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys.
INTRODUCTION: No consensus has been reached regarding the prevalence of metabolic disorders among sudden deafness patients or their influence as associated risk factors.
METHODS: This cross-sectional study enrolled all sudden deafness patients treated in the Otolaryngology Department of the University of São Paulo between January 1996 and December 2006. Patients were subjected to laboratory exams including glucose and cholesterol levels, low-density lipoprotein cholesterol fraction, triglycerides, free T4 and TSH.
RESULTS: The sample comprised 166 patients. We observed normal glucose levels in 101 (81.5%) patients and hyperglycemia in 23 (18.5%) patients, which is significantly different (p < 0.0001) compared to the diabetes mellitus prevalence (7.6%) in the Brazilian population. Cholesterol levels were normal in 78 patients (49.7%) and abnormal in 79 (50.3%) patients, which is significantly different compared to the Brazilian population (p = 0.0093). However, no differences were observed in low-density lipoprotein cholesterol fraction (p = 0.1087) or triglyceride levels (p = 0.1474) between sudden hearing loss patients and the Brazilian population. Normal levels of thyroid hormones were observed in 116 patients (78.4%), and abnormal levels were observed in 32 (21.6%) patients. Compared with the prevalence of thyroid disorders in the general population (10%), statistical analysis revealed a significant difference (p = 0.0132) between these two groups.
DISCUSSION: Among sudden deafness patients, we observed frequencies of hyperglycemia and thyroid disorders that were more than twice those of the general population.
CONCLUSIONS: Hyperglycemia and thyroid disorders are much more frequent in patients with sudden deafness than in the general population and should be considered as important associated risk factors.
Jeanne Oiticica; Roseli Saraiva Moreira Bittar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-18     Completed Date:  2011-10-14     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1149-553     Citation Subset:  IM    
Department of Otolaryngology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
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MeSH Terms
Brazil / epidemiology
Cross-Sectional Studies
Diabetes Complications / epidemiology
Diabetes Mellitus / epidemiology
Hearing Loss, Sudden / epidemiology*
Hyperglycemia / epidemiology
Metabolic Diseases / epidemiology*
Middle Aged
Risk Factors
Thyroid Diseases / epidemiology

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