Document Detail


Metabolic and digestive response to food ingestion in a binge-feeding lizard, the Gila monster (Heloderma suspectum).
MedLine Citation:
PMID:  17872997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrointestinal tract possesses the capacity to change in form and function in response to fasting and feeding. Such plasticity can be dramatic for species that naturally experience long episodes of fasting between large meals (e.g. sit-and-wait foraging snakes, estivating anurans). By contrast, for active foraging species that feed more frequently on smaller meals, gastrointestinal responses are more modest in magnitude. The Gila monster Heloderma suspectum is an active foraging lizard that feeds infrequently on meals weighing up to one-third of its body mass. Additionally, Gila monsters possess a species-specific salivary peptide, exendin-4, which may be involved in the regulation of metabolic and digestive performance. To investigate the adaptive postprandial response of Gila monsters and the potential regulatory role of exendin-4, we measured metabolic and intestinal responses to feeding in the presence or absence of circulating exendin-4. Following the consumption of rodent or egg meals equivalent to 10% of lizard body mass, metabolic rates peaked at 4.0- to 4.9-fold of standard metabolic rates and remained elevated for 5-6 days. Specific dynamic action of these meals (43-60 kJ) was 13-18% of total meal energy. Feeding triggered significant increases in mucosal mass, enterocyte width and volume, and the upregulation of D-glucose uptake rates and aminopeptidase-N activity. Total intestinal uptake capacity for L-leucine, L-proline and D-glucose were significantly elevated within 1-3 days after feeding. Whereas the absence of circulating exendin-4 had no impact on postprandial metabolism or the postprandial response of intestinal structure and nutrient uptake, it significantly increased intestinal aminopeptidase-N activity. Within the continuum of physiological responses to feeding and fasting, Gila monsters occupy an intermediate position in experiencing moderate, though significant, regulation of intestinal performance with feeding.
Authors:
C M Christel; D F DeNardo; S M Secor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  210     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3430-9     Citation Subset:  IM    
Affiliation:
Arizona State University, School of Life Sciences, PO Box 874501, Tempe, AZ 85287, USA. churst@cc.edu
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena
Animals
Digestion / physiology*
Energy Metabolism / physiology*
Feeding Behavior / physiology*
Female
Food
Intestines / anatomy & histology,  physiology
Lizards / physiology*
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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