Document Detail


Metabolic cycles as an underlying basis of biological oscillations.
MedLine Citation:
PMID:  16823381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.
Authors:
Benjamin P Tu; Steven L McKnight
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-07-05
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  7     ISSN:  1471-0072     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-701     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA. bentu@biochem.swmed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks / physiology*
Circadian Rhythm / physiology*
Hibernation / physiology*
Humans
Saccharomyces cerevisiae / physiology*

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