Document Detail


Metabolic correction of gas exchange disturbances in rats with barbiturate coma.
MedLine Citation:
PMID:  15455119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Krebs cycle intermediates normalized gas exchange and decreased the mortality rate in rats with barbiturate coma. Treatment with other substrates including glucose and products of glycolysis was ineffective. Oxygen inhalation had no effect on oxygen consumption and indexes of external respiration. Our results suggest that deficiency of endogenous intermediates of the Krebs cycle, but not disturbances in oxygen mass transfer, serves as a limiting factor for oxygen consumption in rats with barbiturate coma.
Authors:
T V Shefer; Yu Yu Ivnitskii; V N Malakhovskii
Related Documents :
3420139 - Effects of ginkgo biloba constituents related to protection against brain damage caused...
734799 - The kangaroo rat as a model for type i decompression sickness.
10781429 - Vascular remodeling and et-1 expression in rat strains with different responses to chro...
2492769 - Cervical sympathectomy and cerebral microvascular and blood flow responses to hypocapni...
2272129 - Body growth and polycythaemia in hypoxic albino rats of first and second generation.
3094379 - Hepatic heme and drug metabolism in rats with chronic mountain sickness.
7336919 - Radiation-induced parathyroid adenomas and thyroid tumors in rats.
6384949 - Lhrh neurons and their projections in humans and other mammals: species comparisons.
2968489 - The effect of atrial natriuretic peptide on acid-base balance in rats with chronic rena...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  137     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-09-29     Completed Date:  2005-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
Affiliation:
Military Medical Academy, St. Petersburg.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Citric Acid Cycle / physiology
Coma / chemically induced,  metabolism*,  therapy
Female
Oxygen / metabolism
Oxygen Consumption / drug effects*
Oxygen Inhalation Therapy
Rats
Succinates / pharmacology
Thiopental / poisoning*
Chemical
Reg. No./Substance:
0/Succinates; 76-75-5/Thiopental; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dose-dependent effects and specificity of action of antibodies to endogenous regulators in ultralow ...
Next Document:  Effect of M2 muscarinic receptor blockade in rats with haloperidol-produced catatonic syndrome.