Document Detail

Metabolic correction of gas exchange disturbances in rats with barbiturate coma.
MedLine Citation:
PMID:  15455119     Owner:  NLM     Status:  MEDLINE    
Krebs cycle intermediates normalized gas exchange and decreased the mortality rate in rats with barbiturate coma. Treatment with other substrates including glucose and products of glycolysis was ineffective. Oxygen inhalation had no effect on oxygen consumption and indexes of external respiration. Our results suggest that deficiency of endogenous intermediates of the Krebs cycle, but not disturbances in oxygen mass transfer, serves as a limiting factor for oxygen consumption in rats with barbiturate coma.
T V Shefer; Yu Yu Ivnitskii; V N Malakhovskii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  137     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-09-29     Completed Date:  2005-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
Military Medical Academy, St. Petersburg.
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MeSH Terms
Citric Acid Cycle / physiology
Coma / chemically induced,  metabolism*,  therapy
Oxygen / metabolism
Oxygen Consumption / drug effects*
Oxygen Inhalation Therapy
Succinates / pharmacology
Thiopental / poisoning*
Reg. No./Substance:
0/Succinates; 76-75-5/Thiopental; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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