| Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | |
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MedLine Citation:
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PMID: 16213729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Feeding of chemically synthesized [27-13C]codisterol ([27-13C]2), [27-13C]24-epicodisterol ([27-13C]3), [23,24-2H2]codisterol ([23,24-2H2]2), and [26,27-2H6]24-methyldesmosterol ([26,27-2H6]8) to Oryza sativa cell cultures, followed by MS and NMR analysis of the biosynthesized dihydrobrassicasterol (9)/campesterol (10), revealed that both (24R)- and (24S)-epimers of 24-methyl-Delta25-cholesterol (2/3) were converted to 9 and 10 via the common intermediate 24-methyldesmosterol (8). |
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Authors:
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Kyoko Takahashi; Kozue Nasu; Tadahiko Mashino; Masuo Morisaki; Noriyuki Hara; Yoshinori Fujimoto |
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Publication Detail:
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Type: Journal Article Date: 2005-10-06 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 14 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 732-8 Citation Subset: IM |
Affiliation:
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Kyoritsu University of Pharmacy, Shibakoen, Tokyo 105-8512, Japan. takahashi-ky@kyoritsu-ph.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Cholesterol / analogs & derivatives*, biosynthesis, chemistry Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Oryza sativa / metabolism Phytosterols / biosynthesis*, chemistry Plants / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Phytosterols; 474-62-4/campesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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