Document Detail

Metabolic control of the Treg/Th17 axis.
MedLine Citation:
PMID:  23405895     Owner:  NLM     Status:  MEDLINE    
The interplay of the immune system with other aspects of physiology is continually being revealed and in some cases studied in considerable mechanistic detail. A prime example is the influence of metabolic cues on immune responses. It is well appreciated that upon activation, T cells take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; however, a number of recent breakthroughs have greatly expanded our knowledge of how aspects of cellular metabolism can shape a T-cell response. Particularly important are findings that certain environmental cues can tilt the delicate balance between inflammation and immune tolerance by skewing T-cell fate decisions toward either the T-helper 17 (Th17) or T-regulatory (Treg) cell lineage. Recognizing the unappreciated immune-modifying potential of metabolic factors and particularly those involved in the generation of these functionally opposing T-cell subsets will likely add new and potent therapies to our repertoire for treating immune mediated pathologies. In this review, we summarize and discuss recent findings linking certain metabolic pathways, enzymes, and by-products to shifts in the balance between Th17 and Treg cell populations. These advances highlight numerous opportunities for immune modulation.
Joseph Barbi; Drew Pardoll; Fan Pan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-77     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Cell Differentiation
Gene Expression Regulation
Hypoxia-Inducible Factor 1 / genetics,  immunology
Immune Tolerance
Lymphocyte Activation / immunology
Metabolic Networks and Pathways / immunology*
Signal Transduction
T-Lymphocyte Subsets / cytology,  immunology,  metabolism*
T-Lymphocytes, Helper-Inducer / cytology,  immunology,  metabolism*
T-Lymphocytes, Regulatory / cytology,  immunology,  metabolism*
Grant Support
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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