Document Detail


Metabolic consequences of overproduction of phosphoenolpyruvate carboxylase in C3 plants.
MedLine Citation:
PMID:  12781771     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phosphoenolpyruvate carboxylase (PEPC) has a variety of functions in plants, including a major anaplerotic role in replenishing the tricarboxylic acid cycle with intermediates to meet the demand of carbon skeletons for synthesis of organic acids and amino acids. Various transgenic C3 plants that overproduce PEPC have been produced and analyzed in detail. The results indicate that foreign PEPC is under the control of the regulatory mechanisms intrinsic to the host plant and down-regulated so as not to cause detrimental metabolic effects, although the anaplerotic reaction is slightly enhanced by the foreign PEPC. By use of foreign PEPCs that can avert such regulation, metabolic flow is largely directed toward synthesis of organic acids and amino acids. Observations with transgenic C3 plants also shed light on the interrelation among various metabolic pathways inside the cell.
Authors:
Mitsue Miyao; Hiroshi Fukayama
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  414     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2003-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Affiliation:
Photosynthesis Laboratory, National Institute of Agrobiological Sciences, Kannondai, 305-8602, Tsukuba, Japan. mmiyao@affrc.go.jp <mmiyao@affrc.go.jp>
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry
Carbon / chemistry
Down-Regulation
Glycolysis
Models, Biological
Oryza sativa / genetics
Phosphoenolpyruvate Carboxylase / metabolism*,  physiology*
Phosphorylation
Plant Physiological Phenomena
Plants, Genetically Modified
Chemical
Reg. No./Substance:
0/Amino Acids; 7440-44-0/Carbon; EC 4.1.1.31/Phosphoenolpyruvate Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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