Document Detail

Metabolic consequences of acute limb ischemia and their clinical implications.
MedLine Citation:
PMID:  19298933     Owner:  NLM     Status:  MEDLINE    
Acute limb ischemia is a common medical condition resulting from arterial embolization, in situ thrombosis, trauma, and other causes. The severity of injury is related to the duration of ischemia and the effects of reperfusion. Metabolic consequences of reperfusion injury can be variable, ranging from transient symptoms in the lower extremity to systemic inflammation with multiple organ dysfunction. This article provides an overview of some of the key mediators of reperfusion injury. Additional discussion is focused on the clinical effects of reperfusion in the extremity, as well as the pulmonary, cardiac, and renal organ systems. A better understanding of these processes may result in improved patient outcomes and decreased mortality.
Jonathan L Eliason; Thomas W Wakefield
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in vascular surgery     Volume:  22     ISSN:  1558-4518     ISO Abbreviation:  Semin Vasc Surg     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809602     Medline TA:  Semin Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Section of Vascular Surgery, University of Michigan Health System, Ann Arbor, MI 48109-5867, USA.
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MeSH Terms
Acute Disease
Acute Lung Injury / etiology,  metabolism*,  prevention & control
Extremities / blood supply*
Ischemia / complications*,  metabolism,  therapy
Muscle, Skeletal / blood supply
Myocardial Reperfusion Injury / etiology,  metabolism
Reperfusion Injury / etiology,  metabolism*,  prevention & control
Respiratory Distress Syndrome, Adult / etiology,  metabolism*,  prevention & control
Severity of Illness Index
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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