Document Detail


Metabolic changes and mitochondrial dysfunction early following transthoracic countershock in dogs.
MedLine Citation:
PMID:  2478983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms of myocardial injury and necrosis following transthoracic shocks from a direct current cardiac defibrillator were investigated in adult greyhounds. Myocardial lactate extraction became negative maximally at 1 minute, following two (mean -22% +/- SEM23) or five (-193% +/- 135) shocks and returned to baseline in 6-15 minutes. Myocardial necrosis assessed at 4 hours following the shock period was 0.05 g (+/- 0.03) after two shocks, 6.69 g (+/- 1.76) after five shocks and zero in controls. In further experiments, dogs received five or zero (dummy) shocks and mitochondria were isolated from their hearts following excision within 1 minute of receiving the final shock. Maximal oxygen consumption in right ventricular mitochondria was lower than the unshocked controls with both glutamate (66.9 +/- 9.4 nanoatoms of oxygen/mg per minute, n = 9 vs 86.6 +/- 13.6 nanoatoms/mg per minute, n = 7) and succinate (96.2 +/- 8.7 nanoatoms/mg per minute, n = 9 vs 119.5 +/- 14.4 nanoatoms/mg per minute, n = 7) as substrates. Using electron spin resonance spectroscopy, an increase in a peroxyl-free radical with g = 2.031 was detected in myocardial tissue after two internal shocks (50 joules stored energy, 0.5-minute intervals). We conclude that mitochondrial dysfunction and free-radical generation are likely contributors to cellular injury following multiple countershocks.
Authors:
T G Trouton; J D Allen; L K Yong; J J Rooney; A A Adgey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  12     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-18     Completed Date:  1989-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1827-34     Citation Subset:  IM    
Affiliation:
Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electric Countershock / adverse effects*
Electron Spin Resonance Spectroscopy
Female
Free Radicals
Lactates / metabolism
Lactic Acid
Male
Mitochondria, Heart / metabolism*
Myocardium / metabolism,  pathology*
Oxygen Consumption
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Lactates; 50-21-5/Lactic Acid

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