| Metabolic changes in rabbit spinal cord after trauma: magnetic resonance spectroscopy studies. | |
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MedLine Citation:
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PMID: 2913925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combined phosphorus and proton magnetic resonance spectroscopy (MRS), using double-tuned surface coils, was used to monitor certain metabolic changes in the L-3 spinal segment of anesthetized rabbits prior to and following experimental spinal cord trauma. Following severe trauma, resulting in spastic paraplegia, there was a delayed and progressive accumulation of lactic acid, a decline in intracellular pH, and a loss of high-energy phosphates. Maximal alterations occurred between 2 and 3 hours after the trauma, with little further change by 4 hours. Histological examination 2 weeks after trauma showed tissue necrosis and cavitation. These findings support the concept of secondary tissue injury after spinal cord trauma and suggest that early changes in metabolism, as shown by MRS, may predict irreversible tissue damage. |
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Authors:
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R Vink; L J Noble; S M Knoblach; M R Bendall; A I Faden |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of neurology Volume: 25 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-02-28 Completed Date: 1989-02-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 26-31 Citation Subset: IM |
Affiliation:
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Center for Neural Injury, University of California, San Francisco. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy* Male Oxygen / metabolism Phosphates / metabolism Phosphocreatine / metabolism Rabbits Spinal Cord Injuries / metabolism*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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902269//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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