Document Detail


Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy.
MedLine Citation:
PMID:  9776469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used a standardized bicycle ergometry protocol with a stepwise increasing workload (30-100 W) to evaluate various metabolic factors for the diagnosis and metabolic monitoring of mitochondrial encephalomyopathies. All patients (n = 9) showed pathological venous lactate/pyruvate (L/P) ratios, which normalized in three patients after 6 months of coenzyme Q10 (CoQ) therapy. Thus, the L/P ratio proved to be the clinically most useful parameter in the evaluation and monitoring of mitochondrial diseases, showing higher sensitivity than lactate measurements only. CoQ may exert a favourable effect in some patients with mitochondrial diseases.
Authors:
A Chan; H Reichmann; A Kögel; A Beck; R Gold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  245     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-30     Completed Date:  1998-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  681-5     Citation Subset:  IM    
Affiliation:
Neurologische Universitätsklinik, Würzburg.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Case-Control Studies
Coenzymes
Exercise Test
Female
Humans
Male
Middle Aged
Mitochondrial Encephalomyopathies / drug therapy*
Sensitivity and Specificity
Ubiquinone / analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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