Document Detail

Metabolic and cardiovascular changes during physical restrains in rats.
MedLine Citation:
PMID:  7463878     Owner:  NLM     Status:  MEDLINE    
When conscious rats were physically restrained, their body temperature, heart rate and heat production increased within minutes. The rate of increase in heat production was less than that in heart rate, particularly in warm environments. Reduction of oxygen pulse, consequently either stroke volume or (A-V) O2 difference, was suggested. Stroke volume cardiac output and its fractional distribution to most of the calorigenic organs measured by the reference sample method using 85Sr-labelled microspheres decreased significantly by restraint. However, fractional distribution of cardiac output increased greatly to the skeletal muscles. The restraint-hypermetabolism may be attributed to the increased metabolism of the skeletal muscles supported with an increased availability of oxygen. With a slight increase in mean aortic pressure, total peripheral resistance increased greatly as observed during Valsalva-like maneuver. The decrease in cardiac output and stroke volume during restraint may be caused by obstruction to the systemic venous return.
T Nagasaka; K Hirata; H Shibata; Y Sugano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  30     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM; S    
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MeSH Terms
Body Temperature Regulation*
Cardiac Output
Heart Rate*
Muscles / blood supply
Regional Blood Flow
Restraint, Physical*
Stroke Volume

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