Document Detail


Metabolic behavior of alpha-ray activity in large human arteries: relationship to atherosclerosis.
MedLine Citation:
PMID:  845359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paradoxic biologic behavior of tissue calcium metabolism is emphasized. Although calcium salts are essential for the development of bones, they also contribute to aging of the large human arteries. The heavy elements providing alpha-ray activity tend to be metabolized like calcium. The concept of an osteoporosis-atherosclerosis relationship led to a series of investigations in which ash content and alpha-ray activity were examined in abdominal aortas, coronary arteries, pulmonary arteries and, for comparison, in bones and ventral costal cartilages. Both ash content and alpha-ray activity rise with age in the aorta and in the coronary arteries, but there is no such increase in the pulmonary arteries. A statistically significant correlation between ash content and alpha-ray activity has been found only in aortas and coronary arteries. This correlation is even closer in the coronary arteries of subjects who die of coronary artery disease and in the aortas of the elderly. Wet tissue alpha-ray activity in an aorta with severe atherosclerosis may be 220 times higher than in an aorta without significant atherosclerosis. Alpha-activity in bones and in ventral costal cartilages tends to decline in advancing years, though in the cartilages the calcium deposits increase with age. Our studies reveal a close relationship between atherogenesis and the unique metabolic behavior of alpha-ray radiation in the large human arteries.
Authors:
A Elkeles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  25     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Alpha Particles*
Aorta, Abdominal / metabolism
Arteries / analysis*
Arteriosclerosis / metabolism*
Bone and Bones / metabolism
Calcium / metabolism*
Cartilage, Articular / metabolism
Coronary Vessels / metabolism
Female
Humans
Middle Aged
Osteoporosis / metabolism
Pulmonary Artery / metabolism
Ribs / metabolism
Chemical
Reg. No./Substance:
7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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