| Metabolic aspects of maximal exercise performance after slow release metoprolol and after atenolol. | |
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MedLine Citation:
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PMID: 7173299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maximal exercise performance by eight healthy male subjects was tested after one week of medication with slow-release metoprolol 200 mg/d (metoprolol-SR), atenolol 200 mg/d or placebo, in a double blind crossover trial. The maximal working capacity was significantly decreased after atenolol and metoprolol-SR. Plasma glucose and FFA concentrations during the exercise test did not change: either after placebo therapy or after beta-blockade. The anerobic threshold did not change after beta-blockade, but the changes in lactate due to the exercise were less after beta-blockade. Neither beta-blocker affected the exercise-induced alteration in airway resistance. Both drugs caused a small but significant ventilatory depression at rest and at 75% of maximal exercise. It is concluded that the limiting factor in maximal exercise performance after beta 1-adrenergic blockade does not lie in oxygen transport to the working muscles via ventilation and the circulation, but is most probably due to anaerobic metabolism. |
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Authors:
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H T Folgering; J F Borm; R H van Haaren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 23 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-02-14 Completed Date: 1983-02-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atenolol / administration & dosage, metabolism* Delayed-Action Preparations Double-Blind Method Exercise Test Hemodynamics / drug effects Humans Male Metoprolol / administration & dosage, metabolism* Peak Expiratory Flow Rate Physical Exertion* Propanolamines / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Propanolamines; 29122-68-7/Atenolol; 37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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