Document Detail

Metabolic aspects of maximal exercise performance after slow release metoprolol and after atenolol.
MedLine Citation:
PMID:  7173299     Owner:  NLM     Status:  MEDLINE    
Maximal exercise performance by eight healthy male subjects was tested after one week of medication with slow-release metoprolol 200 mg/d (metoprolol-SR), atenolol 200 mg/d or placebo, in a double blind crossover trial. The maximal working capacity was significantly decreased after atenolol and metoprolol-SR. Plasma glucose and FFA concentrations during the exercise test did not change: either after placebo therapy or after beta-blockade. The anerobic threshold did not change after beta-blockade, but the changes in lactate due to the exercise were less after beta-blockade. Neither beta-blocker affected the exercise-induced alteration in airway resistance. Both drugs caused a small but significant ventilatory depression at rest and at 75% of maximal exercise. It is concluded that the limiting factor in maximal exercise performance after beta 1-adrenergic blockade does not lie in oxygen transport to the working muscles via ventilation and the circulation, but is most probably due to anaerobic metabolism.
H T Folgering; J F Borm; R H van Haaren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  23     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
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MeSH Terms
Atenolol / administration & dosage,  metabolism*
Delayed-Action Preparations
Double-Blind Method
Exercise Test
Hemodynamics / drug effects
Metoprolol / administration & dosage,  metabolism*
Peak Expiratory Flow Rate
Physical Exertion*
Propanolamines / metabolism*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Propanolamines; 29122-68-7/Atenolol; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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