Document Detail

Metabolic alterations of toxic and nonessential elements by the treatment of Sempervivum tectorum extract in a hyperlipidemic rat model.
MedLine Citation:
PMID:  14713548     Owner:  NLM     Status:  MEDLINE    
A hyperlipidemic rat model was used to examine the therapeutic effect of Sempervivum tectorum plant extract on the metabolic alterations of Al, As, B, Ba, Cd, Hg, Ni, Pb, and Ti in the liver and bile. Hyperlipidemia was produced by lipogenic diet and alcohol and verified by morphological investigation of the liver with the aid of light and an electron microscope. Element concentration in the liver and bile were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration values in the liver higher than the detection limit (Al, Ba, Ni, Ti) were unambiguous. Significant differences were found for the four groups at p < 0.05 level (ANOVA). A significant difference was observed between Al and B concentration in the bile fluids of the 4 groups (p < 0.05). The excretion of Al and Ti into the bile fluid increased significantly (p < 0.05). Following the administration of S. tectorum extract to rats with hyperlipidemia, the excretion of Al, B and Ba increased, whereas the excretion of Ti decreased significantly (p < 0.05). The favorable action of the extract (protecting the liver in hyperlipidemic rats) was verified by morphological studies, and its detoxicating property was shown by the elimination of Al, Ba, Ni, and Ti from the liver.
Klára Szentmihályi; Erzsébet Fehér; Péter Vinkler; Agnes Kéry; Anna Blázovics
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicologic pathology     Volume:  32     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-01-09     Completed Date:  2004-09-28     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-7     Citation Subset:  IM    
Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary.
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MeSH Terms
Administration, Oral
Antilipemic Agents / administration & dosage,  pharmacokinetics,  therapeutic use*
Bile / drug effects,  metabolism
Crassulaceae / chemistry*
Disease Models, Animal
Drug Administration Schedule
Hepatocytes / drug effects,  ultrastructure
Hyperlipidemias / drug therapy*,  metabolism
Liver / chemistry,  drug effects,  metabolism
Metabolic Detoxication, Drug
Metals / analysis,  metabolism*
Plant Extracts / administration & dosage,  pharmacokinetics,  therapeutic use*
Rats, Wistar
Withholding Treatment
Reg. No./Substance:
0/Antilipemic Agents; 0/Metals; 0/Plant Extracts

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