Document Detail


Metabolic alkalosis with hypoelectrolytemia in infants with cystic fibrosis.
MedLine Citation:
PMID:  11982899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Infants with cystic fibrosis (CF) can develop episodes of hyponatremic hypochloremic dehydration with metabolic alkalosis when they sweat excessively, which is not caused by sweating in normal infants. We investigated the incidence of the metabolic alkalosis with hypoelectrolytemia in CF infants, the possible risk factors for its occurrence and the importance of the manifestation in the diagnosis of CF. METHODS: In order to evaluate the incidence and the risk factors for the development of this sweat-related metabolic disorder in CF, we reviewed the records of all children diagnosed as having CF before the age of 12 months in a 10-year period. Data analysis included medical history data, clinical features, biochemical parameters (blood pH, serum bicarbonate, sodium, chloride and potassium levels), sweat chloride test values, as well as genetic analysis data. RESULTS: The prevalence of metabolic alkalosis in association with low serum electrolyte concentrations (hyponatremia, hypochloremia, and hypokalemia) in infant CF population in our region was 16.5%. We found no season predilection in its occurrence. Early infant age, breast-feeding, delayed CF diagnosis, heat exhaustion and the presence of severe CF transmembrane conductance regulator mutations are predisposed factors for the development of metabolic alkalosis with hypoelectrolytemia. CONCLUSIONS: The results from our study suggest that metabolic alkalosis with hypoelectrolytemia is a relatively common manifestation of CF in infancy. The possibility of CF should be seriously considered in any infant with this metabolic disorder.
Authors:
Stojka Fustik; Nada Pop-Jordanova; Nevenka Slaveska; Svetlana Koceva; Gorgi Efremov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  44     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-01     Completed Date:  2002-07-25     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Clinical Center, Skopje, Republic of Macedonia. fustik@ukim.edu.mk
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MeSH Terms
Descriptor/Qualifier:
Alkalosis / etiology*
Chlorides / blood*
Cystic Fibrosis / complications*,  genetics
Female
Genotype
Humans
Hypokalemia / etiology*
Hyponatremia / etiology*
Infant
Male
Retrospective Studies
Chemical
Reg. No./Substance:
0/Chlorides

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