Document Detail


Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium.
MedLine Citation:
PMID:  15860529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skeletal muscle releases potassium during activity. Interstitial potassium accumulation is important for muscle function and the development of fatigue resulting from exercise. In the present study we used sodium citrate ingestion as a tool to investigate the relationship between interstitial H+ concentration and K+ accumulation during exercise. Seven healthy subjects performed one-legged knee-extensor exercise on two separate days with and without sodium citrate ingestion. Interstitial H+ and K+ concentrations were measured with the microdialysis technique. Citrate ingestion reduced the plasma H+ concentration and increased the plasma HCO3- concentration. Citrate had no effect on interstitial H+ at rest. The increase in interstitial H+ concentration during intense exercise was significantly lower (P < 0.05) with citrate ingestion compared to control (peak interstitial H+ concentration 79 versus 131 nM). After 3 min of exercise interstitial K+ concentration was reduced (P < 0.05) in the citrate (alkalosis) compared to the control experiment (8.0 +/- 0.9 versus 11.0 +/- 2 mM) and interstitial K+ concentration remained lower during the rest of the exercise period. The present study demonstrated a link between interstitial H+ and K+ accumulation, which may be through the ATP-sensitive K+ channels (KATP channels), which are sensitive to changes in H+.
Authors:
Darrin Street; Jens-Jung Nielsen; Jens Bangsbo; Carsten Juel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-28
Journal Detail:
Title:  The Journal of physiology     Volume:  566     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2005-09-27     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  481-9     Citation Subset:  IM    
Affiliation:
Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, August Krogh Building, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism*
Adult
Alkalosis / metabolism*
Bicarbonates / blood
Carbon Dioxide / blood
Exercise / physiology*
Fluorometry
Humans
Hydrogen-Ion Concentration
Male
Microdialysis
Muscle, Skeletal / metabolism*
Potassium / metabolism*
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium
Comments/Corrections

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