| Metabolic agents in the management of diabetic coronary patients: a new era. | |
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MedLine Citation:
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PMID: 18199501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects. |
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Authors:
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Giuseppe Marazzi; Maurizio Volterrani; Giuseppe M C Rosano |
Publication Detail:
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Type: Letter Date: 2008-01-15 |
Journal Detail:
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Title: International journal of cardiology Volume: 127 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-27 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 124-5 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetanilides
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therapeutic use Citric Acid Cycle Coronary Disease / complications*, drug therapy* Diabetes Mellitus, Type 2 / complications* Diabetic Angiopathies / complications* Dichloroacetate / therapeutic use Enzyme Inhibitors / therapeutic use Epoxy Compounds / therapeutic use Humans Insulin Resistance Perhexiline / therapeutic use Piperazines / therapeutic use Trimetazidine / therapeutic use Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Acetanilides; 0/Enzyme Inhibitors; 0/Epoxy Compounds; 0/Piperazines; 0/Vasodilator Agents; 110445-25-5/ranolazine; 13425-80-4/Dichloroacetate; 5011-34-7/Trimetazidine; 6621-47-2/Perhexiline; 82258-36-4/etomoxir |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2008 Jun 23;127(1):133-4
[PMID:
17561287
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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