Document Detail

Metabolic agents in the management of diabetic coronary patients: a new era.
MedLine Citation:
PMID:  18199501     Owner:  NLM     Status:  MEDLINE    
The modulation of cardiac metabolism with Trimetazidine is very important for the control of myocardial ischemia and for the preservation of left ventricular function. The optimization of cardiac metabolism should also include improvement of cardiac insulin resistance with insulin sensitizer agents and the optimization of Kreb's Cycle with essential amino acids. Regarding new drugs that may act inhibiting free fatty acid oxidation we have to underline that to date it is not clear whether Ranolazine has an effect on cardiac metabolism. We agree instead that metabolic agents like Dichloroacetate, Perhexiline and Etomoxir have an antiischemic effect, while their administration requires adjustment of dose and careful monitoring of side effects.
Giuseppe Marazzi; Maurizio Volterrani; Giuseppe M C Rosano
Publication Detail:
Type:  Letter     Date:  2008-01-15
Journal Detail:
Title:  International journal of cardiology     Volume:  127     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  124-5     Citation Subset:  IM    
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MeSH Terms
Acetanilides / therapeutic use
Citric Acid Cycle
Coronary Disease / complications*,  drug therapy*
Diabetes Mellitus, Type 2 / complications*
Diabetic Angiopathies / complications*
Dichloroacetate / therapeutic use
Enzyme Inhibitors / therapeutic use
Epoxy Compounds / therapeutic use
Insulin Resistance
Perhexiline / therapeutic use
Piperazines / therapeutic use
Trimetazidine / therapeutic use
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Acetanilides; 0/Enzyme Inhibitors; 0/Epoxy Compounds; 0/Piperazines; 0/Vasodilator Agents; 110445-25-5/ranolazine; 13425-80-4/Dichloroacetate; 5011-34-7/Trimetazidine; 6621-47-2/Perhexiline; 82258-36-4/etomoxir
Comment In:
Int J Cardiol. 2008 Jun 23;127(1):133-4   [PMID:  17561287 ]

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