Document Detail


Metabolic adjustments during adaptation to high ambient temperature by preoptic-lesioned rats.
MedLine Citation:
PMID:  1823008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic adjustment was studied in male Wistar rats weighing 180-200 g with bilateral electrolytic lesions in the preoptic area which were acclimatized to a hot environment (34 degrees C, 30 rats) and to normal temperature (25 degrees C, 20 rats) for 60 days. Oxygen consumption at 34 degrees C and body weight were measured periodically. Preoptic-lesioned rats (PO rats) showed a reduction in metabolic rate (from 46.2 +/- 2 to 33 +/- 2 Cal/m2 per h, P less than 0.05) regardless of the temperatures to which they were adapted. Although the reduced metabolic rate of PO rats living at 25 degrees C or 34 degrees C could be an indicator of adaptation to heat, only the PO rats living at 25 degrees C showed a weight gain (101 +/- 13 g) similar to that observed for the sham-operated control (75 +/- 11 g). In fact, the PO rats living at 34 degrees C failed to increase their body weight during 60 days of exposure to heat. These data indicate that the preoptic area is essential to integrate the thermal input with the energy-linked metabolic process involved in adaptation to hot environments.
Authors:
G L Santos; J V Leite; C C Coimbra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  24     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1169-72     Citation Subset:  IM    
Affiliation:
Departamento de Fisiologia, Universidade Federal do Pará, Belém, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Animals
Body Weight
Energy Metabolism
Hot Temperature*
Male
Oxygen Consumption / physiology*
Preoptic Area / physiology*
Rats
Rats, Inbred Strains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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