| Metabolic adaptations of liver mitochondria during restricted feeding schedules. | |
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MedLine Citation:
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PMID: 15976385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Food anticipatory activity (FAA) is an output of the food-entrained oscillator (FEO), a conspicuous biological clock that expresses when experimental animals are under a restricted food schedule (RFS). We have shown that the liver is entrained by RFS and exhibits an anticipatory response before meal time in its oxidative and energetic state. The present study was designed to determine the mitochondrial oxidative and phosphorylating capacity in the liver of rats under RFS to further support the biochemical anticipatory role that this organ plays during the food entrainment (9). Metabolic and functional parameters of liver mitochondria were characterized before (0800 h), during (1100 h), and after (1400 h) FAA. The main results were as follows. First, there was an enhancement during FAA (1100 h) in 1) oxidative capacity (site I of the electron transport chain), 2) phosphorylating ability (estimated by ATP synthesis), and 3) activities of NADH shuttles. Second, after rats were fed (1400 h), the phosphorylating capacity remained high, but this was not the case for the respiratory control ratio for site I. Finally, in the three experimental conditions before, during, and after FAA, an increment was detected in the H(+) electrochemical potential, due to an elevation in mitochondrial membrane potential, and in mitochondrial yield. Most of the changes in mitochondrial properties related to RFS were also present when results were compared with those from the 24-h fasted group. In conclusion, the results support the notion that a distinctive rheostatic state is installed in the metabolic activity of the liver when FEO is being expressed. |
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Authors:
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Adrián Báez-Ruiz; Carolina Escobar; Raúl Aguilar-Roblero; Olivia Vázquez-Martínez; Mauricio Díaz-Muñoz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-23 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 289 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-15 Completed Date: 2005-12-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G1015-23 Citation Subset: IM |
Affiliation:
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Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México-Juriquilla, Querétaro, Qro 76001, México. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Citrate (si)-Synthase / metabolism Conditioning, Operant Fasting / metabolism Food Deprivation / physiology* Glutamic Acid / metabolism Malates / metabolism Male Membrane Potentials Mitochondria, Liver / metabolism* Mitochondrial Swelling Rats Rats, Wistar Succinic Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Malates; 110-15-6/Succinic Acid; 56-86-0/Glutamic Acid; 6915-15-7/malic acid; EC 2.3.3.1/Citrate (si)-Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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