Document Detail


Metabolic abnormalities in cachexia and anorexia.
MedLine Citation:
PMID:  11054609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An increased glucose requirement by many solid tumors produces an increased metabolic demand on the liver, resulting in an increased energy expenditure. In addition, several cytokines and tumor catabolic products have been suggested as being responsible for the depletion of adipose tissue and skeletal-muscle mass in cachexia. A sulphated glycoprotein of molecular mass 24 kDa, produced by cachexia-inducing tumors and present in the urine of cancer patients actively losing weight, has been shown to be capable of inducing direct muscle catabolism in vitro and a state of cachexia in vivo, with specific loss of the non-fat carcass mass. In vitro studies have shown the bioactivity of this proteolysis-inducing factor to be attenuated by the polyunsaturated fatty acid, eicosapentaenoic acid. Preliminary clinical studies have shown that eicosapentaenoic acid stabilizes body weight and protein and fat reserves in patients with pancreatic carcinoma. Further trials are required to confirm the efficacy of eicosapentaenoic acid and to determine the anticachectic activity in other types of cancer.
Authors:
M J Tisdale
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  16     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2001-05-31     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1013-4     Citation Subset:  IM    
Affiliation:
Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK. m.j.tisdale@aston.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Anorexia / metabolism*
Cachexia / metabolism*
Carbohydrate Metabolism*
Eicosanoic Acids / therapeutic use
Humans
Lipid Metabolism*
Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Eicosanoic Acids; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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