| Metabolic abnormalities in adults with cystic fibrosis. | |
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MedLine Citation:
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PMID: 20497385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Survival of patients with cystic fibrosis (CF) has improved, resulting in increased exposure of patients to cardiovascular risk factors. Diabetes mellitus is common in patients with CF; however, less is known about lipid abnormalities in this population. In this study, the prevalence of lipid abnormalities was investigated in a contemporary population of adults with CF. METHODS: Clinical and laboratory data on 221 adult patients with CF were collected retrospectively. Fasting serum glucose levels and lipid profiles were recorded. The age-specific values for healthy individuals, as reported by the National Health and Nutrition Examination Surveys, were used for comparison. RESULTS: The mean age of the patients was 30 +/- 10 years, 55.1% were men and the mean FEV(1)% was 68 +/- 25%. Sixty-nine patients (31.2%) had CF-related diabetes mellitus and 52 (23.5%) were receiving insulin therapy. In addition, 36 patients (16.3%) had impaired glucose tolerance. Triglyceride levels were similar to those of historical control subjects (mean +/- SEM, 1.37 +/- 0.05 and 1.39 +/- 0.02 mmol/L, respectively, P = 0.75). However, in the 30-39 years age group of CF patients, triglyceride levels were increased relative to those of their control counterparts (1.79 +/- 0.14 vs 1.38 +/- 0.04 mmol/L, P = 0.006). Total cholesterol levels were lower in the CF patients compared with control subjects, across all age groups. CONCLUSIONS: Abnormalities of glucose metabolism are highly prevalent in CF patients, and are accompanied by hypertriglyceridaemia in the 30-39 years age group. Prospective studies are required to confirm lipid abnormalities and investigate possible cardiovascular complications in patients with CF. |
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Authors:
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Vasiliki V Georgiopoulou; Adam Denker; Kathy L Bishop; Jason M Brown; Benjamin Hirsh; Linda Wolfenden; Laurence Sperling |
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Publication Detail:
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Type: Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 15 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 823-9 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Section of Preventive Cardiology, Emory University, Atlanta, Georgia 30322, USA. vgeorgi@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism* Cholesterol / blood, metabolism Cystic Fibrosis / complications*, metabolism Diabetes Mellitus / blood, drug therapy, etiology, metabolism Female Glucose Metabolism Disorders / complications, epidemiology Hemoglobin A, Glycosylated / analysis Humans Hypertriglyceridemia / complications*, epidemiology* Insulin / therapeutic use Lipid Metabolism Lipids / blood Male Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Lipids; 0/hemoglobin A1c protein, human; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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