| Metabolic Tests to Determine Risk for Type 1 Diabetes in Clinical Trials. | |
| | |
MedLine Citation:
|
PMID: 21488143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: Evaluate the reproducibility and relationship of various metabolic tests conducted as part of the Diabetes Prevention Trial - type 1 diabetes (DPT-1) METHODS: Coefficients of variation, intraclass correlation coefficients, and Pearson correlations between the same metabolic tests performed at different times as well as the different tests were determined. RESULTS: Fasting samples on the same day had a CV of <10 for C-peptide, 11 for insulin and 2 for glucose. Testing on separate days approximately doubled the variance. Stimulated insulin values had less variance than fasting values and there was only a moderate correlation between fasting and stimulated values on each test. While highly correlated, C-peptide values from MMTT are significantly lower than that obtained during OGTT. Neither peak nor AUC C-peptide on OGTT was different between those with abnormal and normal glucose tolerance. Those with abnormal as compared with normal glucose tolerance had lower 30 minute C-peptide and a longer time to peak C-peptide. CONCLUSIONS: A large, multi-center trial, with tests performed over a decade long period can provide robust data. C-peptide data from OGTT and MMTT differ, thus the same stimulation test should be used to evaluate changes in beta cell function over time. Worsening glucose tolerance is associated with lower C-peptide at 30 minutes and a delay in peak secretion on the OGTT. This DPT-1 data can be used in planning parameters for future studies including evaluation of new algorithms to determine risk of disease. Copyright © 2011 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Cj Greenbaum; B Buckingham; Hp Chase; J Krischer |
Related Documents
:
|
18229453 - Altered heat stress response following streptozotocin-induced diabetes. 12472783 - Effects of diabetes, insulin and antioxidants on no synthase abundance and no interacti... 7037403 - Carp insulin: amino acid sequence, biological activity and structural properties. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-12 |
Journal Detail:
|
Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
|
Benaroya Research Institute, Seattle, WA. cjgreen@benaroyaresearch.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of the Chirality of Residues and ?-Turns on the Electronic Excitation Spectra, Excited-State ...
Next Document: Insulin secretion is decreased in non-diabetic individuals with hypomagnesemia.