Document Detail


Metabolic syndrome and urinary stone composition: what factors matter most?
MedLine Citation:
PMID:  22795374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine which metabolic syndrome (MetS) factors lead to differences in stone composition in a multivariate analysis.
METHODS: We retrospectively reviewed medical charts of patients who had a kidney stone removed over a 5-year period (2006-2011). MetS factors (obesity [body mass index {BMI} >30], diabetes mellitus [DM], hypertension [HTN], and dyslipidemia [DLD]) were tallied in each patient. For the latter 3 factors, medical treatment for the condition was used to tag a patient with the condition. Stone composition was determined by the dominant (>50%) component. Statistical analysis was designed to determine which MetS factors were independently associated with differences in stone composition.
RESULTS: Five hundred ninety kidney stones were included in the analysis. Patients with MetS had a higher prevalence of uric acid stones and lower prevalence of calcium phosphate stones. HTN and DM were independently associated with differences in composition, specifically uric acid stones (higher proportion), and calcium phosphate stones (lower proportion). Obesity was not associated with differences in composition, although a secondary analysis of morbidly obese patients showed a higher proportion of uric acid stones and a lower proportion of calcium oxalate stones.
CONCLUSION: HTN and DM are the MetS factors independently associated with differences in stone composition, specifically the uric acid and calcium phosphate components. Obesity has little effect on stone composition until a very high (>40) BMI is reached. The overall effect of MetS factors on stone type is relatively small, because most stones are calcium oxalate and MetS factors have little impact on calcium oxalate frequency.
Authors:
Adam O Kadlec; Kristin Greco; Zachary C Fridirici; Spencer T Hart; Ted Vellos; Thomas M Turk
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Publication Detail:
Type:  Journal Article     Date:  2012-07-13
Journal Detail:
Title:  Urology     Volume:  80     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-31     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Loyola University Medical Center, Department of Urology, Fahey Center, Maywood, IL 60153, USA. akadlec@lumc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcium Oxalate / analysis*
Calcium Phosphates / analysis*
Diabetes Complications / complications,  metabolism
Dyslipidemias / complications,  metabolism
Female
Humans
Hypertension / complications,  metabolism
Kidney Calculi / chemistry*,  complications
Male
Metabolic Syndrome X / complications,  metabolism*
Middle Aged
Multivariate Analysis
Obesity / complications,  metabolism
Retrospective Studies
Uric Acid / analysis*
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid; 97Z1WI3NDX/calcium phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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