| Metabolic Syndrome, Diabetes, Poor Cognition, and Dementia in the Caerphilly Prospective Study. | |
| | |
MedLine Citation:
|
PMID: 22133761 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We have examined whether metabolic syndrome is associated with intermediate risk of impaired cognition between people with and without diabetes. Men aged 45 to 59 years were identified from Caerphilly in South Wales, United Kingdom. Participation rate was 89% (41% of the original cohort) and 2,512 men were examined in phase one from July 1979 until September 1983. Follow-up examinations occurred at four intervals until 2004 when 1,225 men participated. Participants were categorized on the basis of their exposure to metabolic syndrome not diabetes (MSND) and diabetes (with or without metabolic syndrome) at each of the first three phases. Neuropsychological outcomes and clinical diagnosis of cognitive impairment not dementia (CIND) and dementia were assessed at phase five. The prevalence of MSND increased from 1% to 5% and for diabetes from 3% to 9% between phase one and phase three. 15% of participants had CIND and 8% dementia. People with diabetes, but not those with MSND, at phases one, two, or three had poorer cognition at phase five (adjusted β coefficient AH4 -4.3 95% CI -7.9, -0.7; phase two: -2.5 95% CI -4.7, -0.3; phase three: -2.3 95% CI -4.2, -0.5). The adjusted odds ratio (phase one) for diabetes and CIND was 4.0 (95% CI 1.4, 11.5) and dementia 0.61 (95% CI 0.07, 5.37). After adjustment, higher systolic blood pressure was the only component of the metabolic syndrome associated with worse cognitive outcomes. Diabetes in mid-life, but not MSND, is associated with impaired cognition and increased odds of CIND in later life. |
| | |
Authors:
|
Samuel T Creavin; John Gallacher; Antony Bayer; Mark Fish; Shah Ebrahim; Yoav Ben-Shlomo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-1 |
Journal Detail:
|
Title: Journal of Alzheimer's disease : JAD Volume: - ISSN: 1875-8908 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Bristol, School of Social and Community Medicine, Canynge Hall, Bristol, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The 24-bp consensus sequence responsible for regulation of the BphS1T1 two-component system in a hyb...
Next Document: Overexpression of Amyloid-? Protein Precursor Induces Mitochondrial Oxidative Stress and Activates t...