| Metabolic syndrome biomarkers predict lung function impairment: a nested case-control study. | |
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MedLine Citation:
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PMID: 22095549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function. OBJECTIVES: To define if metabolic syndrome biomarkers are risk factors for loss of lung function after irritant exposure. METHODS: A nested case-control study of Fire Department of New York personnel with normal pre-September 11th FEV(1) and who presented for subspecialty pulmonary evaluation before March 10, 2008. We correlated metabolic syndrome biomarkers obtained within 6 months of World Trade Center dust exposure with subsequent FEV(1). FEV(1) at subspecialty pulmonary evaluation within 6.5 years defined disease status; cases had FEV(1) less than lower limit of normal, whereas control subjects had FEV(1) greater than or equal to lower limit of normal. MEASUREMENTS AND MAIN RESULTS: Clinical data and serum sampled at the first monitoring examination within 6 months of September 11, 2001, assessed body mass index, heart rate, serum glucose, triglycerides and high-density lipoprotein (HDL), leptin, pancreatic polypeptide, and amylin. Cases and control subjects had significant differences in HDL less than 40 mg/dl with triglycerides greater than or equal to 150 mg/dl, heart rate greater than or equal to 66 bpm, and leptin greater than or equal to 10,300 pg/ml. Each increased the odds of abnormal FEV(1) at pulmonary evaluation by more than twofold, whereas amylin greater than or equal to 116 pg/ml decreased the odds by 84%, in a multibiomarker model adjusting for age, race, body mass index, and World Trade Center arrival time. This model had a sensitivity of 41%, a specificity of 86%, and a receiver operating characteristic area under the curve of 0.77. CONCLUSIONS: Abnormal triglycerides and HDL and elevated heart rate and leptin are independent risk factors of greater susceptibility to lung function impairment after September 11, 2001, whereas elevated amylin is protective. Metabolic biomarkers are predictors of lung disease, and may be useful for assessing risk of impaired lung function in response to particulate inhalation. |
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Authors:
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Bushra Naveed; Michael D Weiden; Sophia Kwon; Edward J Gracely; Ashley L Comfort; Natalia Ferrier; Kusali J Kasturiarachchi; Hillel W Cohen; Thomas K Aldrich; William N Rom; Kerry Kelly; David J Prezant; Anna Nolan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2011-11-17 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 185 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-16 Completed Date: 2012-05-01 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 392-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollutants, Occupational / adverse effects* Biological Markers / blood Body Mass Index Case-Control Studies Dust* Firefighters* Forced Expiratory Volume Humans Logistic Models Longitudinal Studies Lung Diseases, Obstructive / blood, diagnosis, etiology* Metabolic Syndrome X / blood*, complications Middle Aged New York City Occupational Exposure / adverse effects* Odds Ratio Sensitivity and Specificity September 11 Terrorist Attacks* Spirometry |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1RR029893/RR/NCRR NIH HHS; AL080298A//PHS HHS; HL090316/HL/NHLBI NIH HHS; K23 HL084191/HL/NHLBI NIH HHS; K23HL084191/HL/NHLBI NIH HHS; K24A1080298//PHS HHS; R01HL057879/HL/NHLBI NIH HHS; R01HL090316/HL/NHLBI NIH HHS; T32 ES007267/ES/NIEHS NIH HHS; TL1 RR029892/RR/NCRR NIH HHS; TL1RR029892/RR/NCRR NIH HHS; U01CA008617/CA/NCI NIH HHS; U10-OH008242/OH/NIOSH CDC HHS; U10-OH008243/OH/NIOSH CDC HHS; UL1 RR029893/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Biological Markers; 0/Dust |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2012 Sep 15;186(6):567; author reply 567-8
[PMID:
22984026
]
Am J Respir Crit Care Med. 2012 Feb 15;185(4):352-3 [PMID: 22336675 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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