Document Detail

Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators.
MedLine Citation:
PMID:  23361837     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients with bipolar disorder have high levels of cardiovascular disease risk factors. The presence of metabolic syndrome significantly influences future cardiovascular disease morbidity and mortality. The authors sought to clarify the prevalence and moderators of metabolic syndrome in bipolar patients, accounting for subgroup differences.
METHOD: The authors searched MEDLINE, PsycINFO, EMBASE, and CINAHL through April 2012 for research reporting metabolic syndrome prevalence rates in bipolar patients. Medical subject headings "metabolic syndrome" and "bipolar" were used in the title, abstract, or index term fields. Manual searches were conducted using the reference lists from identified articles.
RESULTS: The search yielded 81 articles in 37 publications (N=6,983). The overall metabolic syndrome rate was 37.3% (95% confidence interval [CI]=36.1-39.0) using any standardized metabolic syndrome criteria. Compared with general population groups, bipolar patients had higher metabolic syndrome rates (odds ratio=1.98; 95% CI=1.74-2.25). In bipolar patients, older age had a modest effect on the metabolic syndrome rate. The strongest moderator was the region in which the study took place, with the highest rates observed in New Zealand and Australia (64.2% [95% CI=38.3-83.9]) and North America (49.3% [95% CI=29.7-69.3]). Metabolic syndrome was significantly more prevalent in patients currently treated with antipsychotics (45.3% [95% CI=39.6-50.9] than in patients who were antipsychotic free (32.4% [95% CI=27.5-37.4]; odds ratio=1.72 [95% CI=1.24-2.38]).
CONCLUSIONS: These findings strongly support the claim that patients with bipolar disorder are at high risk for metabolic syndrome and related cardiovascular morbidity and mortality and require regular monitoring and adequate preventive efforts and treatment for cardio-metabolic risk factors. These findings further suggest that the risk of metabolic syndrome is greater in bipolar patients taking prescribed antipsychotic medication.
Davy Vancampfort; Kristof Vansteelandt; Christoph U Correll; Alex J Mitchell; Amber De Herdt; Pascal Sienaert; Michel Probst; Marc De Hert
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  170     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-01     Completed Date:  2013-04-15     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-74     Citation Subset:  AIM; IM    
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Bipolar Disorder / drug therapy*,  epidemiology*
Cardiovascular Diseases / chemically induced,  epidemiology
Cross-Cultural Comparison
Cross-Sectional Studies
Metabolic Syndrome X / chemically induced*,  epidemiology*
Middle Aged
Risk Factors
Reg. No./Substance:
0/Antipsychotic Agents
Comment In:
Am J Psychiatry. 2013 Aug;170(8):927-8   [PMID:  23903338 ]
Am J Psychiatry. 2013 Aug;170(8):928-9   [PMID:  23903339 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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