| Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults. | |
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MedLine Citation:
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PMID: 22285865 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To determine whether metabolic syndrome is associated with accelerated cognitive decline in community-dwelling older adults. METHODS: A longitudinal study of 993 adults (mean 66.8 ± 8.7 years) from the Rancho Bernardo Study. Metabolic syndrome components, defined by 2001 NCEP-ATP III criteria, were measured in 1984-1987. Cognitive function was first assessed in 1988-1992. Cognitive assessments were repeated approximately every 4 years, for a maximum 16-year follow-up. Mixed-effects models examined longitudinal rate of cognitive decline by metabolic syndrome status, controlling for factors plausibly associated with cognitive function (diabetes, inflammation). RESULTS: Metabolic syndrome was more common in men than women (14% vs. 9%, p = .01). In women, metabolic syndrome was associated with greater executive function and long-term memory decline. These associations did not differ by inflammatory biomarker levels. Diabetes did not alter the association of metabolic syndrome with long-term recall but modified the association with executive function: metabolic syndrome was associated with accelerated executive function decline in diabetic women only. Metabolic syndrome was not related to rate of decline on any cognitive measure in men. CONCLUSIONS: Metabolic syndrome was a risk factor for accelerated cognitive decline, but only in women. Prevention of metabolic syndrome may aid in maintenance of cognitive function with age. |
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Authors:
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Linda K McEvoy; Gail A Laughlin; Elizabeth Barrett-Connor; Jaclyn Bergstrom; Donna Kritz-Silverstein; Claudia Der-Martirosian; Denise von Mühlen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
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Title: Annals of epidemiology Volume: - ISSN: 1873-2585 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100013 Medline TA: Ann Epidemiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, University of California, San Diego, La Jolla, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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