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Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS.
MedLine Citation:
PMID:  22272014     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and identify biomarkers involved in toxicity onset. Here, we summarize the metabolic fingerprints for detection and identification of metabolic changes and biomarkers related to drug-induced toxicity using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
Authors:
Mina Hasegawa; Mika Ide; Mitsuru Kuwamura; Jyoji Yamate; Shigeo Takenaka
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Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Journal of toxicologic pathology     Volume:  23     ISSN:  1881-915X     ISO Abbreviation:  J Toxicol Pathol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9306408     Medline TA:  J Toxicol Pathol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  -    
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