| Metabolic Diversity of Progressive Kidney Disease in 325 Patients with Type 1 Diabetes (the FinnDiane Study). | |
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MedLine Citation:
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PMID: 22204613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Type 1 diabetic patients with varying severity of kidney disease were investigated to create multi-metabolite models of the disease process. Urinary albumin excretion rate was measured for 3 358 patients with type 1 diabetes. Prospective records were available for 1 051 patients, of whom 162 showed progression of albuminuria (8.3-year follow-up), and 163 were selected as stable controls. At baseline, serum lipids, lipoprotein subclasses and low-molecular weight metabolites were quantified by NMR spectroscopy (325 samples). The data were analyzed by the self-organizing map. In cross-sectional analyses, patients with no complications had low serum lipids, less inflammation and better glycemic control, whereas patients with advanced kidney disease had high serum cystatin-C and sphingomyelin. These phenotype extremes shared low unsaturated fatty acids (UFAs) and phospholipids. Prospectively, progressive albuminuria was associated with high UFAs, phospholipids, IDL and LDL lipids. Progression at longer duration was associated with high HDL lipids, whereas earlier progression was associated with poor glycemic control, increased saturated fatty acids (SFAs), and inflammation. Diabetic kidney disease consists of diverse metabolic phenotypes: UFAs, phospholipids, IDL and LDL may be important in the subclinical phase, high SFAs and low HDL suggest accelerated progression, and the sphingolipid pathway in advanced kidney injury deserves further research. |
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Authors:
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Ville-Petteri Mäkinen; Tuulia Tynkkynen; Pasi Soininen; Tomi Peltola; Antti J Kangas; Carol Forsblom; Lena M Thorn; Kimmo Kaski; Reino Laatikainen; Mika Ala-Korpela; Per-Henrik Groop |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Journal of proteome research Volume: - ISSN: 1535-3907 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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