| Metabolic Cycles in a Circannual Hibernator. | |
| | |
MedLine Citation:
|
PMID: 21540299 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Hibernation as manifested in ground squirrels is arguably the most plastic and extreme of physiological phenotypes in mammals. Homeostasis is challenged by prolonged fasting accompanied by heterothermy, yet must be facilitated for survival. We performed LC and GC-MS metabolomic profiling of plasma samples taken reproducibly during seven natural stages of the hibernator's year, three in summer and four in winter (each n ≥ 5), employing a non-targeted approach to define the metabolite shifts associated with the phenotype. 231 named metabolites were quantified; 106 of these altered significantly, demarcating a cycle within a cycle where torpor-arousal cycles recur during the winter portion of the seasonal cycle. A number of robust hibernation biomarkers that alter with season and winter stage are identified, including specific free fatty acids, antioxidants, and previously unpublished modified amino acids that are likely to be associated with the fasting state. The major pattern in metabolite levels is one of either depletion or accrual during torpor, followed by reversal to an apparent homeostatic level by interbout arousal. This finding provides new data which strongly support the predictions of a long-standing hypothesis that periodic arousals are necessary to restore metabolic homeostasis. |
| | |
Authors:
|
L Elaine Epperson; Anis Karimpour-Fard; Lawrence E Hunter; Sandra L Martin |
Related Documents
:
|
16003939 - In search of the nature of specific nucleic acid-protein interactions. 11540049 - Thermal synthesis of amino acids and the origin of life. 99139 - Comparative studies on two ferredoxins from the cyanobacterium nostoc strain mac. 6840699 - Amino-acid sequence of two trypsin isoinhibitors, itd i and itd iii from squash seeds (... 1567369 - Glutathione transferase isoenzymes from bufo bufo embryos at an early developmental stage. 9501519 - Gene cloning and characterization of thermostable lipase from bacillus stearothermophil... 3723289 - Identification of sialic acids on the cell surface of hyphae and conidia of the human p... 16902329 - Amino acid requirements of infants and children. 7295649 - Carbon-13 nuclear magnetic resonance spectroscopic study of teichuronic acid from micro... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: Physiological genomics Volume: - ISSN: 1531-2267 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Colorado School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The champions' mitochondria: Is it genetically determined? A review on mitochondrial DNA and elite a...
Next Document: Transcriptional profiling reveals a role for ROR{alpha} in regulating gene expression in obesity-ass...