| Metabolic and clinical effects of the supplementation of a functional mixture of amino acids in cerebral hemorrhage. | |
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MedLine Citation:
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PMID: 20972646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oral supplementation of a specific mixture of essential and non-essential amino acids has been shown to modulate hypercatabolism in patients with chronic heart failure, leading to improved clinical outcome. The aim of this study was to test whether such effects could be replicated in an acute clinical model of hypercatabolism. METHODS: After approval by the Ethics Committee, patients with acute brain hemorrhage admitted to the Neurosurgical ICU were randomly assigned to receive enterally for 14 days 20% of their estimated nitrogen requirements as a standard protein supplement (control group; n = 9) or as a functional amino acid mixture (Aminotrofic®, Errekappa Euroterapici; study group; n = 10). Metabolic and clinical outcome measures were monitored. RESULTS: In the study group, insulin sensitivity and total lymphocyte count appeared to improve when compared with control patients. Less positive blood cultures were found in the study group against control patients (4 vs. 7, respectively; P = 0.05). Also, mortality in the study group was reduced than in control patients (60 vs. 77%; P = n.s.). CONCLUSIONS: Supplementation with specific amino acids in critically ill patients may modulate metabolic response and improve clinical outcome. |
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Authors:
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Alessandro Laviano; Flavia Aghilone; Donato Colagiovanni; Federica Fiandra; Roberta Giambarresi; Paolo Tordiglione; Alessio Molfino; Maurizio Muscaritoli; Giovanni Rosa; Filippo Rossi Fanelli |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Neurocritical care Volume: 14 ISSN: 1556-0961 ISO Abbreviation: Neurocrit Care Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-19 Completed Date: 2011-05-03 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 44-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, Sapienza University, Rome, Italy. alessandro.laviano@uniroma1.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Adolescent Adult Aged Amino Acids / administration & dosage* Brain / drug effects*, metabolism Cerebral Hemorrhage / drug therapy*, metabolism, mortality Critical Care / methods* Energy Metabolism / drug effects* Female Humans Male Middle Aged Morbidity Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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