Document Detail

Metabolic basis for the self-referential genetic code.
MedLine Citation:
PMID:  21057876     Owner:  NLM     Status:  In-Data-Review    
An investigation of the biosynthesis pathways producing glycine and serine was necessary to clarify an apparent inconsistency between the self-referential model (SRM) for the formation of the genetic code and the model of coevolution of encodings and of amino acid biosynthesis routes. According to the SRM proposal, glycine was the first amino acid encoded, followed by serine. The coevolution model does not state precisely which the first encodings were, only presenting a list of about ten early assignments including the derivation of glycine from serine-this being derived from the glycolysis intermediate glycerate, which reverses the order proposed by the self-referential model. Our search identified the glycine-serine pathway of syntheses based on one-carbon sources, involving activities of the glycine decarboxylase complex and its associated serine hydroxymethyltransferase, which is consistent with the order proposed by the self-referential model and supports its rationale for the origin of the genetic code: protein synthesis was developed inside an early metabolic system, serving the function of a sink of amino acids; the first peptides were glycine-rich and fit for the function of building the early ribonucleoproteins; glycine consumption in proteins drove the fixation of the glycine-serine pathway.
Romeu Cardoso Guimarães
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Publication Detail:
Type:  Journal Article     Date:  2010-11-06
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  41     ISSN:  1573-0875     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  357-71     Citation Subset:  IM; S    
Lab. Biodiversidade e Evolução Molecular, Dept. Biologia Geral, Inst. Ciências Biológicas, Univ. Federal de Minas Gerais, 31270.901, Belo Horizonte, MG, Brazil,
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